There are approximately 40 prescription medicines approved by the FDA in a nasal spray formulation. Many include antihistamines and steroids to treat seasonal allergies (e.g., Flonase) and are available as generic (and OTC) medicines. Others include medicines such as Imitrex (sumatriptan) to treat migraines that are also available in injectable and oral forms. Nasal spray drugs can be locally or centrally-acting and are easily and quickly absorbed through the nasal mucosa for rapid relief. For patients fearful of needles, a nasal spray is a less threatening, convenient alternative when available.

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